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Los resultados de dos ensayos indican que los pacientes con un EF de 2 pueden experimentar una mejoría de los síntomas.

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In this phase 3, open-label study, we randomly assigned previously untreated patients in East Asia who had advanced pulmonary adenocarcinoma and who were nonsmokers or former light smokers to receive gefitinib (250 mg per day) (609 patients) or carboplatin (at a dose calculated to produce an area under the curve of 5 or 6 mg per milliliter per minute) plus paclitaxel (200 mg per square meter of body-surface area) (608 patients).

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The BCR-ABL tyrosine kinase, the product of the chimeric gene produced by the Philadelphia (Ph) chromosome, is the molecular abnormality that causes chronic myeloid leukemia (CML).

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Although clinical trials are needed to confirm these positive findings, the data suggest that treatment with gefitinib may be beneficial for some Chinese patients who do not respond to chemotherapy and have poor prognosis.

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Because of the intrinsic characteristic of early lymphatic and hematogenous metastasis and extensive local invasion and resistance to chemotherapy, the current 5-year survival rate for pancreatic cancer is less than 4%.

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Table 1 reviews the trials evaluating continuation maintenance.

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Histology was simply subdivided into the intestinal type and diffuse type according to Lauren's classification.

Gefitinib (Iressa, ZD-1839), a small molecule tyrosine kinase inhibitor (TKI) of the epidermal growth factor receptor (EGFR) pathway, is currently under investigation in clinical trials for the treatment of colorectal cancer (CRC).

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Numerous nonrandomized studies of FDG-PET scanning have evaluated mediastinal lymph nodes using surgery (i.

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The contribution of the Lyn protein to the total tyrosine kinase activity within the nuclear matrix is unknown, however; because the Lyn was extracted only partially, an accurate measurement of its activity could not be managed.

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This patient population is at risk of both empirical undertreatment resulting in poor survival or excessive toxicity from standard therapy.

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Cells were plated in 24-well dish and treated twice with increasing doses of gefitinib, followed by cell counting after a 4-day culture.

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The PDQ Adult Treatment Editorial Board uses a in developing its level-of-evidence designations.

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EGF receptor gene mutations are common in lung cancers from “never smokers“ and are associated with sensitivity of tumors to gefitinib and erlotinib.

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Epidermal Growth Factor Receptor (EGFR) Pathway Biomarkers in the Randomized Phase III Trial of Erlotinib Versus Observation in Ovarian Cancer Patients with No Evidence of Disease Progression after First-Line Platinum-Based Chemotherapy.

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He was judged to be intolerant to further cytotoxic chemotherapy in consideration of his physical condition.

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EGFR, a transmembrane tyrosine kinase receptor, is an important regulator of critical events occurring during oncogenesis and tumor progression, such as cell proliferation, inhibition of programmed cell death, angiogenesis, invasion, and metastasis ().

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We also showed that FOXM1 repression by gefitinib is mediated at the transcriptional and promoter levels, as a reduction in FOXM1 mRNA transcripts and a decrease in promoter activity were seen following treatment with gefitinib in sensitive cell lines.

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Numerous nonrandomized, prospective, and retrospective studies have demonstrated that FDG-PET scanning seems to offer diagnostic advantages over conventional imaging in staging distant metastatic disease; however, standard FDG-PET scans have limitations.

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