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Both environmental factors and genetics are associated with alcoholism with about half the risk attributed to each.

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Does abstinence for long periods of time help polysubstance dependent individuals to recover cognitive functioning?

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Alcoholism or alcohol dependence is defined by the American Medical Association (AMA) as "a primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations.

Although many studies have looked at cognitive impairments of individuals who are dependent on one drug, there are few researchers who have tried to determine the problems with cognitive functioning that are caused by dependence on multiple substances.

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For example, psychosis can be caused by use or abuse of or withdrawal from numerous substances and even prescription medications, including amphetamines, phencyclidine (PCP), marijuana, tobacco or marijuana dipped in formaldehyde, hallucinogens, cocaine, alcohol, steroids, anticonvulsants, and anti-parkinsonian medications.

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The effectiveness of disulfiram requires patient compliance with taking the drug as prescribed.

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